BETASIANIN SEBAGAI ANTIKANKER PAYUDARA
Abstract
Breast Cancer (BC) adalah penyebab kematian kedua terbanyak di Amerika setelah kanker paru paru. Amerika Serikat pada tahun 2018, diperkirakan 2500 kejadian kanker payudara akan didiagnosis pada pria dan lebih dari 40.000 perempuan diperkirakan meninggal karena kanker payudara pada tahun 2016. Beberapa alternative pengobatan kanker payudara adalah breast conservation therapy (BCT), Whole-breast radiotherapy (WBRT), breast-conserving surgery (BCS), endocrine therapies (ETs), dan aromatase inhibitors (AIs). Alternatif pengobatan kanker payudara (BC) menyebabkan multiple drug resistance (MDR) dan akhirnya terapi gagal dilakukan. Betasianin merupakan kelompok senyawa flavonoid dengan aktivitas antioksidan, antiradikal, antimikroba dan antikanker yang dapat dikembangkan sebagai antikanker. Betasianin tidak menimbulkan efek samping pada pasien CRC. Artikel ini merupakan review aktivitas betasianin untuk menurunkan resiko kanker payudara (BC) yang ditinjau dari mekanisme molekuler, kemampuan proliferasi sel kanker dan mempromosikan apoptosis sel BC
Keywords
Full Text:
PDFReferences
Akram, M., Iqbal, M., Daniyal, M., & Khan, A. U. (2017). Awareness and current knowledge of breast cancer. Biological Research, 1–23. https://doi.org/10.1186/s40659-017-0140-9
Amrane, M. (n.d.). Breast cancer classification using machine learning. 2018 Electric Electronics, Computer Science, Biomedical Engineerings’ Meeting (EBBT), 1–4.
Asadi K, Ferguson LR, Philpott M, Karunasinghe N. Cancer-preventive Properties of an Anthocyanin-enriched Sweet Potato in the APC MIN Mouse Model . J Cancer Prev. 2017;22(3):135–46
Asra, R., Yetti, R. D., Rusdi, R., Audina, S., & Nessa, N. (2019). Studi Fisikokimia Betasianin Dalam Kulit Buah Naga dan Aplikasinya Sebagai Pewarna Merah Alami Sediaan Farmasi. Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal), 5(2), 140–146. https://doi.org/10.22487/j24428744.2019.v5.i2.13498
Bars-Cortina D, Martínez-Bardají A, Macià A, Motilva MJ, Piñol-Felis C. Consumption evaluation of one apple flesh a day in the initial phases prior to adenoma/adenocarcinoma in an azoxymethane rat colon carcinogenesis model. J Nutr Biochem [Internet]. 2020;83:108418. Available from: https://doi.org/10.1016/j.jnutbio.2020.108418
Bonilla, J. A. M., Tabanera, M. T., & Mendoza, L. H. R. (2017). Breast cancer in the 21st century : From early detection to new therapies ଝ. Radiología (English Edition), 59(5), 368–379. https://doi.org/10.1016/j.rxeng.2017.08.001
Coy-barrera, E. (2020). Analysis of betalains (betacyanins and betaxanthins). 593–619. https://doi.org/10.1016/B978-0-12-816455-6.00017-2
Condello M, Pellegrini E, Spugnini EP, Baldi A, Amadio B, Vincenzi B, et al. Anticancer activity of “Trigno M”, extract of Prunus spinosa drupes, against in vitro 3D and in vivo colon cancer models. Biomed Pharmacother. 2019;118(May).
CHEN L, CHEN MY, SHAO L, ZHANG W, RAO T, ZHOU HH, et al. Panax notoginseng saponins prevent colitis-associated colorectal cancer development: the role of gut microbiota. Chin J Nat Med [Internet]. 2020;18(7):500–7. Available from: http://dx.doi.org/10.1016/S1875-5364(20)30060-1
Dai, X., Cheng, H., Bai, Z., & Li, J. (2017). J o u r n a l o f C a n c e r Breast Cancer Cell Line Classification and Its Relevance with Breast Tumor Subtyping. 8. https://doi.org/10.7150/jca.18457
Davies, C., Ch, B., Taylor, C., Ch, B., Ph, D., Mcgale, P., Ph, D., Peto, R., Pritchard, K. I., Bergh, J., Ph, D., Dowsett, M., Ph, D., & Hayes, D. F. (2017). 20-Year Risks of Breast-Cancer Recurrence after Stopping Endocrine Therapy at 5 Years. https://doi.org/10.1056/NEJMoa1701830
Dumas, A., Luis, I. V., Bovagnet, T., Mouhebb, M. El, & Meglio, A. Di. (2019). original reports abstract Impact of Breast Cancer Treatment on Employment : Results of a Multicenter Prospective Cohort Study ( CANTO ). https://doi.org/10.1200/JCO.19.01726
Ezzati, M., Yousefi, B., Velaei, K., & Safa, A. (2020). Jo ur l P re of. Life Sciences, 117463. https://doi.org/10.1016/j.lfs.2020.117463
Esmeeta A, Adhikary S, Dharshnaa V, Swarnamughi P, Ummul Maqsummiya Z, Banerjee A, et al. Plant-derived bioactive compounds in colon cancer treatment: An updated review. Biomed Pharmacother [Internet]. 2022;153:113384. Available from: https://doi.org/10.1016/j.biopha.2022.113384
Fern, M. F., Reina-p, I., Astorga, J. M., Rodr, A., Plaza-d, J., & Fontana, L. (n.d.). Breast Cancer and Its Relationship with the Microbiota. 2012, 1–20. https://doi.org/10.3390/ijerph15081747
Fragoso MF, Romualdo GR, Vanderveer LA, Franco-Barraza J, Cukierman E, Clapper ML, et al. Lyophilized açaí pulp (Euterpe oleracea Mart) attenuates colitis-associated colon carcinogenesis while its main anthocyanin has the potential to affect the motility of colon cancer cells. Food Chem Toxicol [Internet]. 2018;121(August):237–45. Available from: https://doi.org/10.1016/j.fct.2018.08.078
Guadano Sharon H. (2018). Breast Cancer in Men. 2311–2320. https://doi.org/10.1056/NEJMra1707939
Harbeck, N., Cortes, J., Gnant, M., Houssami, N., Poortmans, P., Ruddy, K., Tsang, J., & Cardoso, F. (n.d.). Breast cancer. https://doi.org/10.1038/s41572-019-0111-2
Hamedi S, Koosha M. Designing a pH-responsive drug delivery system for the release of black-carrot anthocyanins loaded in halloysite nanotubes for cancer treatment. Appl Clay Sci [Internet]. 2020;197(July):105770. Available from: https://doi.org/10.1016/j.clay.2020.105770
Jain, V., Kumar, H., Anod, H. V, Chand, P., Gupta, N. V., Dey, S., & Kesharwani, S. S. (2020). Jo ur l P re of. In Journal of Controlled Release. Elsevier B.V. https://doi.org/10.1016/j.jconrel.2020.07.003
Kang, S. Y., Kim, Y. S., Kim, Z., Kim, H., Lee, S. K., Jung, K., Youn, H. J., & Breast, K. (2018). Breast Cancer Basic Findings Regarding Breast Cancer in Korea in 2015 : Data from a Breast Cancer Registry. 21(1), 1–10.
Kubow S, Iskandar MM, Melgar-Bermudez E, Sleno L, Sabally K, Azadi B, et al. Effects of simulated human gastrointestinal digestion of two purple-fleshed potato cultivars on anthocyanin composition and cytotoxicity in colonic cancer and non-tumorigenic cells. Nutrients. 2017;9(9):1–17.
Leong, H. Y., Show, P. L., Lim, M. H., Ooi, C. W., & Ling, T. C. (2018). Natural red pigments from plants and their health benefits: A review. Food Reviews International, 34(5), 463–482. https://doi.org/10.1080/87559129.2017.1326935
Lestari, F., & Dewi, K. (2020). Effects of humic acid on vegetative growth, yield, oxalic acid and betacyanin content of red amaranth (Amaranthus tricolor L.). AIP Conference Proceedings, 2260(September). https://doi.org/10.1063/5.0015774
Li, J., & Han, X. (2018). Author ’ s Accepted Manuscript. Current Problems in Cancer. https://doi.org/10.1016/j.currproblcancer.2018.01.004
Presentation, C. (2019). Breast Cancer Treatment A Review. 321(3). https://doi.org/10.1001/jama.2018.19323
Rocha, M., Chaves, N., & Báo, S. (n.d.). Nanobiotechnology for Breast Cancer Treatment Nanobiotechnology for Breast Cancer Treatment.
Roriz, C. L., Barros, L., Prieto, M. A., Morales, P., & Ferreira, I. C. F. R. (2017). Floral parts of Gomphrena globosa L. as a novel alternative source of betacyanins: Optimization of the extraction using response surface methodology. Food Chemistry, 229, 223–234. https://doi.org/10.1016/j.foodchem.2017.02.073
Sheth, D. (2019). Arti fi cial Intelligence in the Interpretation of Breast Cancer on MRI. 1–15. https://doi.org/10.1002/jmri.26878
Trapani, D., Esposito, A., Criscitiello, C., Mazzarella, L., Minchella, I., Minucci, S., & Curigliano, G. (2017). Ac ce pt us cr t. Expert Opinion on Investigational Drugs, 0(0). https://doi.org/10.1080/13543784.2017.1353077
Videira, M., & Brito, M. A. (2017). Brain metastasization of breast cancer. BBA - Reviews on Cancer. https://doi.org/10.1016/j.bbcan.2017.03.004
Wan, X., Guo, H., Liang, Y., Zhou, C., Liu, Z., Li, K., Niu, F., Zhai, X., & Wang, L. (2020). The physiological functions and pharmaceutical applications of inulin: A review. Carbohydrate Polymers, 246. https://doi.org/10.1016/J.CARBPOL.2020.116589
Xi Y, Xu P. Global colorectal cancer burden in 2020 and projections to 2040. Transl Oncol [Internet]. 2021;14(10):101174. Available from: https://doi.org/10.1016/j.tranon.2021.101174
Yadav, S., Boddicker, N. J., Samara, R., Klebba, J., Ambrosone, C. B., Culver, H. A., Auer, P., Bandera, E. V, Bernstein, L., Bertrand, K. A., Burnside, E. S., Carter, B. D., Eliassen, H., Gapstur, S. M., Gaudet, M., Haiman, C., Hodge, J. M., Hunter, D. J., Jacobs, E. J., … Goldgar, D. E. (2021). A Population-Based Study of Genes Previously Implicated in Breast Cancer. https://doi.org/10.1056/NEJMoa2005936
Zhang H, Guo J, Mao L, Li Q, Guo M, Mu T, et al. Up-regulation of MIR-24-1-5p is involved in the chemoprevention of colorectal cancer by black raspberry anthocyanins. Br J Nutr. 2019;122(5):518–26.
Zhang Y, Lin Y, Huang L, Tekliye M, Rasheed HA, Dong M. Composition, antioxidant, and anti-biofilm activity of anthocyanin-rich aqueous extract from purple highland barley bran. Lwt [Internet]. 2020;125(February):109181. Available from: https://doi.org/10.1016/j.lwt.2020.109181
DOI: https://doi.org/10.30743/cheds.v7i1.6588
Refbacks
- There are currently no refbacks.
Copyright (c) 2023 Wilsa Restu Verrira
This work is licensed under a Creative Commons Attribution 4.0 International License.
CHEDS: Journal of Chemistry, Education, and Science
Program Studi Pendidikan Kimia, FKIP - Universitas Islam Sumatera Utara
Kampus Induk UISU Jl. Sisingamangaraja XII Teladan, Medan
Email: pend.kimia@fkip.uisu.ac.id | cheds@fkip.uisu.ac.id
