Efektivitas Gummy Candy Nanosimplisia Bonggol Nanas (Ananas comosus) Terhadap Jamur Candida albicans

Juli Yosa Mega, Jekson Martiar Siahaan, Sofia Rahmi, Novarianti Marbun


Abstract


Infeksi jamur yang disebabkan oleh Candida albicans masih menjadi salah satu masalah kesehatan yang sering ditemukan di masyarakat. Penggunaan obat antijamur sintetik dalam jangka panjang dapat menimbulkan efek samping dan resistensi sehingga diperlukan alternatif pengobatan berbasis bahan alam. Bonggol nanas (Ananas comosus) diketahui mengandung senyawa bioaktif seperti bromelain, flavonoid, tannin, dan fenolik yang berpotensi sebagai antijamur. Penelitian ini bertujuan untuk mengetahui efektivitas gummy candy nanosimplisia bonggol nanas terhadap pertumbuhan Candida albicans serta mengevaluasi karakteristik fisik dan nanopartikel sediaan. Penelitian ini merupakan penelitian eksperimental laboratorium menggunakan rancangan post test only control group design. Bonggol nanas diekstraksi menggunakan metode maserasi dengan pelarut etanol 96%, kemudian dibuat nanosimplisia menggunakan metode ultrasonikasi. Nanosimplisia diformulasikan dalam bentuk gummy candy dengan variasi konsentrasi F0 (tanpa nanosimplisia), F1 (5%), F2 (7,5%), dan F3 (10%). Evaluasi sediaan meliputi organoleptik, pH, keseragaman bobot, kadar air, tekstur, stabilitas, ukuran partikel, zeta potensial, dan indeks polidispersi (PDI). Aktivitas antijamur diuji menggunakan metode difusi sumuran terhadap Candida albicans. Hasil penelitian menunjukkan bahwa seluruh formula memiliki karakteristik fisik yang baik dan stabil selama penyimpanan 30 hari. Formula F3 menghasilkan ukuran partikel terkecil yaitu 142,8 ± 5,1 nm, nilai zeta potensial -34,5 ± 1,1 mV, dan nilai PDI 0,214 ± 0,01 yang menunjukkan sistem nanopartikel stabil dan homogen. Uji aktivitas antijamur menunjukkan bahwa formula F3 memiliki aktivitas tertinggi dengan diameter zona hambat sebesar 21,37 ± 0,62 mm yang termasuk kategori kuat dan mendekati kontrol positif Nystatin sebesar 24,63 ± 0,55 mm. Berdasarkan hasil penelitian dapat disimpulkan bahwa gummy candy nanosimplisia bonggol nanas berpotensi dikembangkan sebagai sediaan antijamur herbal terhadap Candida albicans

Keywords


Gummy candy, nanosimplisia, bonggol nanas, antijamur, Candida albicans

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References


Ahmed, N., Rahman, T., and Yusuf, M. (2022). Characterization and stability evaluation of herbal nanoparticles for oral delivery systems. Pharmaceutics, 14(5), 1021–1033. https://doi.org/10.3390/pharmaceutics14051021.

Brown, D., Wilson, J., and Taylor, S. (2025). Advances in nanoherbal formulations for oral antifungal delivery systems. Nanomedicine, 52, 102701. https://doi.org/10.1016/j.nano.2025.102701.

Chen, L., Huang, Y., and Zhao, X. (2024). Influence of phenolic compounds on texture and stability of functional gummy products. Food Chemistry, 430, 137210. https://doi.org/10.1016/j.foodchem.2024.137210.

Gupta, S., Verma, R., and Singh, D. (2025). Nanoherbal drug delivery systems for antifungal therapy. International Journal of Pharmaceutics, 658, 124562. https://doi.org/10.1016/j.ijpharm.2025.124562.

Hassan, F., Ibrahim, M., and Khalid, A. (2023). Nanoherbal technology in improving antifungal activity against Candida species. Journal of Nanomaterials, 2023, 5548123. https://doi.org/10.1155/2023/5548123.

Johnson, T., Williams, P., and Carter, L. (2023). Polyphenolic compounds improve stability and antimicrobial activity of nanoparticles. Scientific Reports, 13, 29398. https://doi.org/10.1038/s41598-023-29398-8.

Kim, J., Lee, Y., and Park, H. (2024). Nanoencapsulation enhances antimicrobial activity of plant-derived compounds. Heliyon, 10(6), e28754. https://doi.org/10.1016/j.heliyon.2024.e28754.

Kumar, P., Sharma, V., and Rao, S. (2023). Ultrasonication-assisted preparation of herbal nanoparticles and their physicochemical properties. Applied Sciences, 13(14), 8187. https://doi.org/10.3390/app13148187.

Lee, H., Kim, S., and Park, J. (2021). Development of nanoparticle systems containing plant extracts as antifungal agents. Journal of Drug Delivery Science and Technology, 63, 102478. https://doi.org/10.1016/j.jddst.2021.102478.

Martinez, C., Rivera, P., and Gomez, L. (2024). Physicochemical stability of gummy candies fortified with herbal extracts. International Journal of Food Science, 2024, 6678214. https://doi.org/10.1155/2024/6678214.

Oliveira, R., Santos, M., and Lima, J. (2023). Antifungal activity of flavonoid-rich plant extracts against Candida albicans. Pharmaceutical Biology, 61(1), 455–463. https://doi.org/10.1080/13880209.2023.2189455.

Pereira, M., Silva, L., and Costa, R. (2022). Bromelain and phenolic compounds from pineapple waste as natural antimicrobial agents. Molecules, 27(18), 5874–5886. https://doi.org/10.3390/molecules27185874.

Pratiwi, E., Nugroho, A., and Saputra, R. (2024). Evaluation of nanoparticle dispersion using polydispersity index and zeta potential. Journal of Pharmaceutical Investigation, 54(3), 225–234. https://doi.org/10.1007/s40005-024-00561-2.

Rahman, A., Putra, D., and Kurniawan, F. (2024). Pineapple bioactive compounds and their applications in pharmaceutical preparations. Journal of Functional Foods, 112, 105942. https://doi.org/10.1016/j.jff.2024.105942.

Santos, P., Almeida, R., and Costa, F. (2025). Effect of gelatin concentration on gummy candy texture and stability. Food Hydrocolloids, 156, 109845. https://doi.org/10.1016/j.foodhyd.2025.109845.

Sharma, R., Gupta, P., and Singh, A. (2021). Nanoformulation of herbal bioactive compounds for antimicrobial applications. International Journal of Biological Macromolecules, 183, 1234–1245. https://doi.org/10.1016/j.ijbiomac.2021.05.112.

Tanaka, M., Suzuki, T., and Yamamoto, K. (2025). LC-MS profiling of bioactive compounds from pineapple by-products. Journal of Molecular Liquids, 412, 125421. https://doi.org/10.1016/j.molliq.2025.125421.

Wijaya, H., Lestari, D., and Putri, N. (2025). Antifungal mechanisms of bromelain and phenolic compounds from pineapple. Phytomedicine, 135, 155902. https://doi.org/10.1016/j.phymed.2025.155902.

Wulandari, D., Prasetyo, B., and Sari, N. (2022). Formulation and evaluation of herbal gummy candy containing plant extracts. Journal of Applied Pharmaceutical Science, 12(4), 45–53. https://doi.org/10.7324/JAPS.2022.120406.

Zhang, Y., Li, X., and Chen, H. (2022). Zeta potential and particle size analysis in nanoherbal formulations. Frontiers in Chemistry, 10, 879527. https://doi.org/10.3389/fchem.2022.879527..




DOI: https://doi.org/10.30743/best.v9i1.14192

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