Polimer Dalam Sediaan Patch Transdermal Berbasis Teknologi Nanopartikel

Tasya Afriani Saputri, Devi Ratnasari, Kharisma Zahrotul Aulia


Abstract


Sistem penghantaran obat transdermal (TDDS) merupakan metode non-invasif yang meningkatkan efektivitas terapi, namun penetrasi obat sering terhambat oleh stratum korneum. Teknologi nanopartikel dikembangkan untuk memperbaiki kelarutan, stabilitas, dan permeabilitas obat, dengan polimer berperan penting dalam mengatur pelepasan dan kestabilan patch. Kajian ini menelaah secara naratif untuk menganalisis peran polimer alami, semi-sintetik, dan sintetik dalam patch transdermal berbasis nanopartikel. Hasil menunjukkan bahwa polimer alami unggul dalam biokompatibilitas, semi-sintetik memberikan kestabilan mekanik, dan sintetik menawarkan fleksibilitas serta kontrol pelepasan optimal

Keywords


polimer, patch transdermal, nanopartikel, polimer cerdas, penghantaran obat

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References


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DOI: https://doi.org/10.30743/best.v8i2.14501

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